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Frank Zaucke Selected Research

Pseudoachondroplasia

8/2013Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.
1/2011A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis.
10/2006Disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired cartilage oligomeric matrix protein secretion.
1/2004Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP).
8/2002Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways.

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Frank Zaucke Research Topics

Disease

14Osteoarthritis
12/2021 - 03/2010
7Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
02/2018 - 10/2006
6Wounds and Injuries (Trauma)
07/2021 - 01/2018
5Inflammation (Inflammations)
12/2021 - 09/2013
5Pseudoachondroplasia
08/2013 - 08/2002
4Intervertebral Disc Degeneration
03/2020 - 01/2016
4Neuralgia (Stump Neuralgia)
11/2019 - 06/2012
3Rheumatoid Arthritis
08/2021 - 10/2018
2Fibrosis (Cirrhosis)
01/2018 - 02/2016
2type 2 alpha 1 Collagenopathy
03/2010 - 06/2004
1Body Weight (Weight, Body)
01/2021
1Osteophyte
01/2021
1Pathologic Processes
01/2021
1Mucolipidoses (Sialidosis)
11/2020
1Bone Resorption
08/2020
1Synovitis
05/2019
1Osteoporosis
12/2018
1type 1 Stickler syndrome
02/2018
1Pain (Aches)
01/2017
1Systemic Scleroderma (Systemic Sclerosis)
01/2017
1Combined Pituitary Hormone Deficiency
11/2016
1Dwarfism
11/2016
1Peripheral Nerve Injuries
06/2016
1Hyperalgesia
02/2015
1Joint Diseases (Joint Disease)
02/2015
1Mucopolysaccharidoses
02/2015
1Psoriasis (Pustulosis Palmaris et Plantaris)
09/2013
1Arthritis (Polyarthritis)
09/2013
1Hyperplasia
09/2013
1Hypersensitivity (Allergy)
06/2012
1Cystic Kidney Diseases (Cystic Kidney Disease)
05/2010
1Gout
05/2010
1Hypertension (High Blood Pressure)
05/2010
1Hyperuricemia
05/2010

Drug/Important Bio-Agent (IBA)

13CollagenIBA
10/2018 - 01/2004
8Cartilage Oligomeric Matrix ProteinIBA
12/2021 - 08/2002
8Proteins (Proteins, Gene)FDA Link
12/2018 - 01/2004
6Matrilin ProteinsIBA
10/2018 - 07/2007
4Adrenergic Receptors (Adrenergic Receptor)IBA
01/2021 - 03/2020
3EnzymesIBA
07/2021 - 02/2015
3Norepinephrine (Noradrenaline)FDA LinkGeneric
01/2021 - 06/2019
3AntibodiesIBA
10/2018 - 06/2012
3Aggrecans (Aggrecan)IBA
10/2017 - 07/2007
2Neurotransmitter Agents (Neurotransmitter)IBA
01/2021 - 06/2019
2Gabapentin (Neurontin)FDA LinkGeneric
11/2019 - 02/2015
2Calcium Channels (Calcium Channel)IBA
11/2019 - 06/2016
1Peptides (Polypeptides)IBA
12/2021
1Transforming Growth Factors (Transforming Growth Factor)IBA
12/2021
1InosineFDA Link
08/2021
1Adenosine (Adenocard)FDA LinkGeneric
08/2021
1N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime (PUGNAC)IBA
07/2021
1Glucosamine (Dona)IBA
07/2021
1HexosaminesIBA
07/2021
1LeptinIBA
01/2021
1Adrenergic Agents (Adrenergic Drugs)IBA
01/2021
1salicylhydroxamic acid (SHAM)IBA
01/2021
1CatecholaminesIBA
01/2021
1Epinephrine (Adrenaline)FDA LinkGeneric
01/2021
1Diphosphonates (Bisphosphonates)IBA
08/2020
1Pregabalin (Lyrica)FDA Link
11/2019
1Analgesics (Analgesic Drugs)IBA
11/2019
1ElastinIBA
10/2019
1Transforming Growth Factor beta (TGF-beta)IBA
10/2019
1Netrin-1IBA
10/2019
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
10/2019
1Tryptophan (L-Tryptophan)FDA Link
05/2019
1GadoliniumIBA
05/2019
1Rheumatoid FactorIBA
05/2019
1Actins (F Actin)IBA
12/2018
1plastinIBA
12/2018
1AutoantibodiesIBA
10/2018
1C-Type Lectins (C-Type Lectin)IBA
10/2018
1Fibrillin-2IBA
10/2018
1Extracellular Matrix ProteinsIBA
10/2018
1Arginine (L-Arginine)FDA Link
02/2018
1Cysteine (L-Cysteine)FDA Link
02/2018
1Bleomycin (Blenoxane)FDA LinkGeneric
01/2018
1Parathyroid Hormone-Related ProteinIBA
01/2017
1SphingolipidsIBA
01/2017
1Sphingosine-1-Phosphate ReceptorsIBA
01/2017
1Indicators and Reagents (Reagents)IBA
01/2017
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
11/2016
1Hormones (Hormone)IBA
11/2016
1GlycosaminoglycansIBA
02/2015
1Leucine (L-Leucine)FDA Link
02/2015
1Proteoglycans (Proteoglycan)IBA
02/2015
1Antisense OligonucleotidesIBA
02/2015
1FibromodulinIBA
02/2015
1ThrombospondinsIBA
02/2015
1BiglycanIBA
02/2015
1Biomarkers (Surrogate Marker)IBA
10/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2013
1Doxycycline (Periostat)FDA LinkGeneric
09/2013
1OligodeoxyribonucleotidesIBA
06/2012
1SaltsIBA
05/2010
1UromodulinIBA
05/2010

Therapy/Procedure

6Therapeutics
01/2021 - 01/2015
1Diskectomy (Discectomy)
01/2017
1Ligation
06/2012
1Spinal Injections
06/2012